Prognostic Significance of Nucleated RBCs in Predicting Mortality Among ST-Elevation Myocardial Infarction Patients Admitted to the ICU

Background The nucleated red blood cells (NRBCs) are a readily available hematological parameter with potential for risk stratification mortality. Therefore, our objective was to assess the predictive significance of NRBCs ICU mortality among ST-elevation myocardial infarction (STEMI) patients admitted an ICU. Additionally, we aimed compare capacity that acute physiology and chronic health evaluation (APACHE) II score sequential organ failure assessment (SOFA) score. Methodology This descriptive cross-sectional study conducted in National Institute Cardiovascular Diseases (NICVD) Karachi, Pakistan, from 1st February 30th June, 2023. We included adult (≥18 years) diagnosed STEMI who were subsequently assessed all over up five days at 24-hour intervals, highest NRBC levels used final analysis. Furthermore, APACHE SOFA also documented. Patients monitored throughout their stay, any adverse events or complications, such as re-intubation, bleeding necessitating transfusion, requirement renal replacement therapy, arrhythmias, re-infarction, mortality, recorded. Results 151 patients, whom 97 (64.2%) male, average age 61.1 ± 10.7 years. positive had higher mean scores (7.4 2.9 vs. 5.4 2.6; p < 0.001) (14.6 6.3 12.6 5.5; = 0.037) compared those negative NRBCs. culprit vessel showed greater stenosis (%) (98.8 3.0% 96.8 5.7%; 0.004). Post-procedure thrombolysis (TIMI) flow grade III lower (77.8% 91.8% NRBCs, respectively). Moreover, experienced significantly rates (63% 8.2%; 0.001), occurrence arrhythmias (35.2% 19.6%; 0.034), increased vasopressors/inotropic support (96.3% 71.1%; demonstrated superior discriminatory ability scores, area under curve 0.818 (95% CI: 0.738-0.899) 0.774 0.692-0.857) SOFA, 0.707 0.613-0.801) II. Positive exhibited sensitivity 81.0% specificity 81.7% predicting Conclusion In conclusion, emerge robust reliable prognostic indicator, strongly associated elevated patients. power surpasses both scoring systems.